What is the connection between LDH levels and myelofibrosis?

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Question from Carol:  
What is the connection between LDH levels and myelofibrosis? 

Answer from Dr. Leclair
Lactate dehydrogenase (LD) is an enzyme that is found in almost every cell of the body. When cells are damaged or die (in the normal course of things), they release their rather small amount of LD into the bloodstream where it can be excreted by the kidneys (hence, the presence of it).  But when someone has a condition that increases the damaged/dying of cells, the LD will increase. So LD does not specify MF—just the presence of damaged/dead cells. But if you are in a state in which MF is either expected (as a consequence of some other condition such as one of the other myeloproliferative neoplasms), then an increase can be reasonably inferred as part of the progression of the disease.

Please remember the opinions expressed on Patient Power are not necessarily the views of our sponsors, contributors, partners or Patient Power. Our discussions are not a substitute for seeking medical advice or care from your own doctor. That’s how you’ll get care that’s most appropriate for you. 

Have a question for the experts? Send them to questions@patientpower.info.

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Page last updated on April 25, 2019