Which Patients Qualify for Calreticulin Testing? | Transcript | Myeloproliferative Neoplasms | Patient Power


Which Patients Qualify for Calreticulin Testing?

Please remember the opinions expressed on Patient Power are not necessarily the views of our sponsors, contributors, partners or Patient Power. Our discussions are not a substitute for seeking medical advice or care from your own doctor. That’s how you’ll get care that’s most appropriate for you. 

Tamara Lobban-Jones:

We got a question from Jean.  Jean noticed a note on her lab report: Submit peripheral blood for calreticulin testing.  She wants to know, what is this, and what kind of conversation should she be having with her hematologist?

Dr. Leclair:

We now know a whole lot more about myeloproliferative neoplasms than we did before.  A little bit of history because—but not all the way back to the Egyptians, so not to worry—is that we didn't understand genetic processes until the 21st century.  We're still getting to understand them.  In 2006, we found the JAK2 and thought, well, this is it, this is the key to myeloproliferatives, except even up to maybe two years ago or so ET was a diagnosis of exclusion.  That meant you didn't have myelofibrosis and you didn't have p. vera, but you had these funny values, so I guess that had to be essential thrombocythemia.  

Calreticulin is a gene that controls the formation of reticulin and fibrosis, something that's—and platelets, something that's very commonly abnormal in essential thrombocythemia.  So this note was saying, gee, golly, wiz, we don't actually know what's going on here, but there's a lot of platelets floating around or there's a lot of other issues here, and in my guess would be you should probably try this test.  That's kind of the description of it.  It's relatively new.  The name kind of gives it away.  Reticulin, you know it's talking about fibrosis. 

Please remember the opinions expressed on Patient Power are not necessarily the views of our sponsors, contributors, partners or Patient Power. Our discussions are not a substitute for seeking medical advice or care from your own doctor. That’s how you’ll get care that’s most appropriate for you. 

Advertisement
Join Our Community Register for Events Read Our Latest Blog
Advertisement

Page last updated on August 6, 2015