Potential significance of an enhanced level of lambda protein in MGUS

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Question from Robert:
My lab tests for MGUS always come back with normal kappa lambda ratios and levels, but the test always has the language that "There is enhancement of protein in the lambda region."  What, if any, is the potential significance of this enhanced level of lambda protein?

Answer from Dr. Leclair:

As one ages, glitches can happen. One of the more common is a slight increase in one or the other light chains. To make things muddier, it is hard to determine if the increase is due to increased synthesis or decreased breakdown.

There is a condition called monoclonal gammopathy of uncertain significance (MGUS), which sometimes exists by itself or sometimes gradually changes into multiple myeloma.

Please remember the opinions expressed on Patient Power are not necessarily the views of our sponsors, contributors, partners or Patient Power. Our discussions are not a substitute for seeking medical advice or care from your own doctor. That’s how you’ll get care that’s most appropriate for you. 

Have a question for the experts? Send them to questions@patientpower.info.

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Page last updated on September 28, 2015