Is raised protein in urine a concern in CLL?

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Question from Fran:

My husband, 57, was told two years ago he has CLL and is in watch and wait. He's well, plays football and cycles. Just beginning to feel slightly more tired but otherwise is great. His latest blood test (we go every two months) showed Hb112 (started at 134), WBC218 (started at 120), neutrophils 35 (started at 6.6), platelets 190 (started at 179). We've been told he'll need to start FCR soonish (we're in the UK), but now his urine test shows slightly raised protein levels. Is this significant?  

Answer from Dr. Leclair:

I would suspect that the protein is due to the changes from the leukemia. He has doubled his white cell count, and those cells will create a toxic compound when they die in the bloodstream/bone marrow. That stuff is dealt with by the kidneys, so you are seeing stress from that.

A drop from 134 to 112 is a significant item. Either there is a major change in the marrow, or he is having some early RBC death (hemolysis). Both are again putting toxic end products into the bloodstream.

While the protein alone is not a reason to being therapy, I suspect that his physician will start to think about sooner rather than soonish.

 

Please remember the opinions expressed on Patient Power are not necessarily the views of our sponsors, contributors, partners or Patient Power. Our discussions are not a substitute for seeking medical advice or care from your own doctor. That’s how you’ll get care that’s most appropriate for you. 

Have a question for the experts? Send them to questions@patientpower.info.
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Page last updated on April 25, 2019