Do M spike levels impact neutrophil/lymphocyte percentages?

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Question from Bryan:

I have a quantitative M spike level. Does that have any effect on neutrophil/lymphocyte percentages? If the neutrophil/lymphocyte levels become elevated or low, is there a direct correlation with M spike levels? I have multiple myeloma. 

Dr. Leclair: 

While the plasma cells are a form of B lymphocytes, they are found almost exclusively in the bone marrow and lymph nodes. Because they do not look like lymphocytes in the peripheral blood, bone marrow OR lymph nodes, it was thought until rather recently that they were a totally different cell line. 

As a consequence, there is no influence in the peripheral blood differential. Remember that it is better for you to follow the absolute differential numbers and not the percentages, which can be misleading.

Please remember the opinions expressed on Patient Power are not necessarily the views of our sponsors, contributors, partners or Patient Power. Our discussions are not a substitute for seeking medical advice or care from your own doctor. That’s how you’ll get care that’s most appropriate for you. 

Have a question for the experts? Send them to questions@patientpower.info.

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Page last updated on February 3, 2015